About

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I am a Wellcome Trust and The Royal Society funded Sir Henry Dale Research Fellow based at the Centre for Genomics and Child Health at the Blizard Institute, Barts and the London School of Medicine and Dentistry, London, U.K.. The broad aim of my research is to understand the context in which immune responses to infectious pathogens develop in order to improve disease control strategies in resource-poor settings. To this end I characterise patterns of cellular immune responses using samples collected from human populations in sub-Saharan Africa before and after treatment interventions for human immunodeficiency virus (HIV), neglected tropical diseases (NTDs) and malnutrition. I run parallel laboratory-based investigations of the mechanisms underlying these population-level patterns using in vitro cell culture and infection models.

My fellowship aims to understand the relationship between innate immune cell anti-bacterial function and acquisition of bacterial infections over the course of nutritional rehabilitation from severe acute malnutrition (SAM). The study combines longitudinal assessment of blood immune cell responses to bacterial antigens with clinical data from children admitted to three hospitals in Zambia and Zimbabwe with SAM and at 4 time-points after their initial admission. In concert I am exploring how the systemic inflammatory environment in children with SAM affects signalling in healthy immune cells.

For more details about my research please go to my Projects and Publications pages.

You can contact me directly via email (c.bourke@qmul.ac.uk).

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